RT - Journal TY - JOUR A1 - Ezejiofor, Ifeoma A1 - Odesanmi, Williams A1 - Odujoko, Oluwole A1 - Komolaefe, Akinwumi A1 - Alade, Tosin A1 - Olaofe, Rinde A1 - Ibe, Ibeh T1 - Pathologic findings in prostate gland at autopsy with topographic distribution of these diseases within the prostatic zones: Eleven-month prospective study in Oauthc, Ile-Ife, Nigeria YR - 2020//1 JF - New Nigerian Journal of Clinical Research JO - N Niger J Clin Res SP - 44 OP - 49 VO - 9 IS - 16 UL - https://www.mdcan-uath.org/article.asp?issn=2250-9658;year=2020;volume=9;issue=16;spage=44;epage=49;aulast=Ezejiofor;t=5 DO - 10.4103/nnjcr.nnjcr_20_20 N2 - Introduction: Different zones of prostate harbor different prostatic pathology. The peripheral zone shows majorly prostatic adenocarcinoma, which is among the common causes of cancer death in men in sub-Saharan Africa. Aim: The study aimed to determine the spectrum of prostate pathologies in routine autopsies of adult male 30 years and above whose death was unrelated to prostate diseases. Methods: A total of eighty cases of prostate glands were harvested over an 11-month period. These glands were fixed for 48 h, grossed, and processed. The hematoxylin- and eosin-stained slides were examined using multiheaded microscope. Results: The age range of patients was 30–85 years with a mean age of 41.84 ± 12.63 years standard deviation. The most common cause of death in these patients was trauma secondary to road traffic accident followed by cardiovascular diseases. The most common lesions in each prostatic zone as observed in this study were chronic prostatitis 26.3% in the central zone; nodular hyperplasia 16.3% in the transitional zone; prostatic atrophy (13.8%) and adenocarcinoma (8.3%) in the posterior peripheral zone (one of the cases (1.3%) showed multiple carcinomatous foci); and chronic prostatitis 15.0% in the anterior fibromuscular zone. Four patients' ages 30, 31, 32, and 48 years had Schistosoma haematobium infections observed in the seminal vesicles, whereas patient aged 48 years had in addition adenocarcinoma of prostate gland and prostatic atrophy (PA). A case (1.3%) of prostatic calculi and simple cyst of the prostate was seen in ages 56 and 85 years, respectively. Conclusion: Different zones of the prostate are associated with different disease entities, and S. haematobium show an association with adenocarcinoma of prostate in one individual ER -